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Selective and Sensitive Furazolidone Biosensor Based on DNA-Modified TiO2-Reduced Graphene Oxide, 346. Ali A. Ensafi, Mahboobeh Sohrabi, Mehdi Jafari-Asl and Behzad Rezaei, Applied Surface Sci., 2015, 356, 301-307.

In this study, a new methodology was used to develop a novel and sensitive electrochemical DNA biosensor for determination of furazolidone. This biosensor was fabricated from TiO 2 -reduced
graphene oxide (rGO) modified-carbon paste electrode (CPE) decorated with ds-DNA. The oxidation signals of guanine and adenine were used as probes to study the interactions, using
differential pulse voltammetry. By interaction of furazolidone with the ds-DNA, the oxidation peaks current of guanine and adenine were decreased at the modified-CPE. A linear dependence of
the guanine and adenine oxidation signals with furazolidone concentration were observed in the range of 1.0–150.0 pmol L-1 with a detection limit of0.55 and 0.43 pmol L−1 based on
guanine and adenine signals, respectively. The relative standard deviation for five replicate measurements of 10.0 pmol L−1 furazolidone was 4.3%. The influence of potential interfering compounds
on the selectivity was studied. This biosensor was successfully applied for determination of trace amounts of furazolidone in real samples.

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