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Nanostructure–Based Electrochemical Sensor for Determination of Glutathione in Hemolyzed Erythrocytes and Urine, Ali A. Ensafi, M. Monsef, and H. Karimi–Maleh, J. Anal. Chem., 2014, 69(9), 892-898.

Abstract—A sensitive and selective electrochemical method was developed for the determination of glu
tathione (GSH) in hemolysed erythrocyte using vinylferocene modified carbon nanotubes paste electrode
(VFMCNTPE). The results indicate that the electrode is efficient in terms of its electrocatalytic activity for
the oxidation of GSH, leading to a reduced overpotential by more than 470 mV. Also, the values of catalytic
rate constant (k), and diffusion coefficient (D) for GSH were calculated. The electrocatalytic oxidation peak
current of GSH showed two linear dynamic ranges with a detection limit of 0.09 μM GSH. The linear cali
bration ranges were obtained between 0.2–4.0 and 4.0–250.0 μM GSH using square wave voltammetry
(SWV) method. The proposed method was also examined as a selective, simple and precise electrochemical
sensor for the determination of GSH in real samples such as urine and hemolysed erythrocyte.

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