Determination of amiloride using a ds-DNA-modified pencil graphite electrode based on guanine and adenine signals

Authors: Elham Mirmomtaz, Ali A Ensafi, S Soleimanian-Zad

Publication date: 2009/1/1

Journal name: Electrochimica Acta

Volume: 54

Pages: 1141-1146

Publisher: Pergamon

A sensitive electrochemical procedure based on ds-DNA interaction with amiloride at a ds-
DNA-modified pencil graphite electrode (PGE) was introduced as a promising tool for
determination of amiloride. An adsorptive stripping voltammetry was applied for the
immobilization of ds-DNA on PGE in acetate buffer (pH 4.8). Differential pulse voltammetry
(DPV) was carried out to obtain the change in the oxidation signal intensity of guanine and
adenine before and after interaction with amiloride. The decrease in intensity of the ...