This paper presents new two electrochemical sensors based on Ag nanoparticles (AgNPs) decorated an-
chored type ligands, those were prepared based on synthesizing of two amine compounds bounded to
silica support, to detect glucose. These compounds were characterized using transmission electron mi-
croscopy (TEM) and Fourier transform infrared (FT-IR) spectroscopy. TEM monitored AgNPs around 10 nm
in size. These electrocatalytic properties of the modified carbon paste electrodes (CPEs) were investi-
gated by electrochemical techniques including cyclic voltammetry (CV), electrochemical impedance spec-
troscopy (EIS) and hydrodynamic amperometry. According to amperometric studies, the better glucose
sensor represented the detection range of 28.6 μ mol/L to 9.80 mmol/L glucose, with detection limit of
5.5 μ mol/L and sensitivity of 540.7 μ A/mM. In this work, three human blood serums were employed as
real samples with satisfactory results.