A new sensor for electrochemical determination of captopril using chlorpromazine as a mediator at a glassy carbon electrode

Authors: Ali A Ensafi, A Arabzadeh

Publication date: 2012/5/1

Journal name: Journal of Analytical Chemistry

Volume: 67

Pages: 486-496

Publisher: SP MAIK Nauka/Interperiodica

Abstract A new simple, selective and rapid cyclic voltammetric method is reported for the
accurate and precise determination of captopril using chlorpromazine as a suitable
electrocatalyst. It has been shown by cyclic voltammetry, single step chronoamperometry
and electrochemical impedance spectroscopy that chlorpromazine can catalyze the
oxidation of captopril in aqueous buffer solution and produces a sharp oxidation peak
current at about 0.625 V vs. saturated calomel reference electrode. The catalytic oxidation ...