Nanohybrid Organic-Inorganic Chitosan/Dopamine/TiO2 Composites with Controlled Drug-Delivery Properties, M. Safari, M. Ghiaci M. Jafari-Asl, Ali A. Ensafi, Applied Surface Science, 2015, 342, 26-33.
In our present study, a series of nanohybrid composites of dopamine (DOP)/chitosan (CIS)@TiO2 were synthesized by sol–gel method and the drug release of the composites was investigated by using elec-trochemical determination and UV–vis absorbance techniques. DOP/CIS (10–40 wt%) composites wereprepared by dissolving DOP in the chitosan aqueous solution. Then DOP/CIS composites were coatedwith different amounts of TiO2(10–50 wt%) by using titanium tetra n-butoxide, as precursor. Formationof intercalated DOP/CIS@TiO2 nanohybrid composites was characterized by FT-IR, FE-SEM, DSC, BET and XRD analysis. Zeta potential of the best DOP/CIS@TiO2 nanohybrid composite was determined 45.0 and59.1 mV. Compared to the DOP/CIS composites, incorporation of the TiO2enhanced the drug entrapmentconsiderably, and reduced the drug release. The DOP/CIS composites without TiO2 coating released thewhole drug after 10 min in pH 7.4 solution while the TiO2 coated composites released the entrappeddrug after 16 h. The results are very satisfactory and might be used in altering the DOP utilization frominjection to oral.