Simultaneous determination of captopril and thioguanine in pharmaceutical compounds and blood using cathodic adsorptive stripping voltammetry

Authors: Ali Asghar Ensafi, Reza Hajian

Publication date: 2008

Journal name: J. Braz. Chem. Soc

Volume: 19

Pages: 405-412

A reliable, highly selective and sensitive procedure is presented for simultaneous
determination of captopril and thioguanine based on cathodic adsorptive stripping of Cu (I)-
captopril and Cu (I)-thioguanine complexes on a hanging mercury drop electrode. Captopril
and thioguanine were preconcentrated onto the surface of hanging mercury drop electrode
using Cu (II) as a suitable probe, with accumulation time of 90 s. Then the preconcentrated
complexes were analyzed by cathodic stripping differential pulse voltammetry. The effect ...