Voltammetric determination of trace quantities of 6-thioguanine based on the interaction with DNA at a mercury electrode

Authors: Elham Mirmomtaz, Ali Asghar Ensafi

Publication date: 2009/7/15

Journal name: Electrochimica Acta

Volume: 54

Pages: 4353-4358

Publisher: Pergamon

Herein, a sensitive square wave voltammetric (SWV) method is described for the quantitative
determination of an anticancer drug, 6-thioguanine (6-TG). The interaction of 6-TG with
double stranded DNA (ds-DNA) in the solution phase resulted in a well amplified SWV
response at the surface of hanging mercury dropping electrode (HMDE). Accumulation and
stripping steps were made in the sample medium conditioned with acetate buffer (pH 4.8).
Optimized conditions for the accumulation step included the deposition potential at− 0.10 ...