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Simultaneous chemiluminescence determination of amoxicillin and clavulanic acid using least squares support vector regression

Authors: F Hasanpour, Ali A Ensafi, T Khayamian
Publication date:: 2010/6/18
Journal name: Analytica Chimica Acta
Volume: 670
Pages: 44-50
Publisher: Elsevier
 
In this work, both the batch and flow injection chemiluminescence (CL) methods have been
proposed for the simultaneous determination of two structurally similar β-lactams including
amoxicillin and clavulanic acid (CLAV). Chemiluminescence spectral overlap of these two
structurally similar β-lactams is the main limitation for the simultaneous analysis of the two
compounds. Least squares support vector regression (LS-SVR) was applied to relate
concentration of both the compounds to their CL profiles. The parameters of the model, ...

http://www.sciencedirect.com/science/article/pii/S0003267010005714

Journal Papers
Month/Season: 
June
Year: 
2010

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