Simultaneous chemiluminescence determination of amoxicillin and clavulanic acid using least squares support vector regression

Authors: F Hasanpour, Ali A Ensafi, T Khayamian

Publication date:: 2010/6/18

Journal name: Analytica Chimica Acta

Volume: 670

Pages: 44-50

Publisher: Elsevier

In this work, both the batch and flow injection chemiluminescence (CL) methods have been
proposed for the simultaneous determination of two structurally similar β-lactams including
amoxicillin and clavulanic acid (CLAV). Chemiluminescence spectral overlap of these two
structurally similar β-lactams is the main limitation for the simultaneous analysis of the two
compounds. Least squares support vector regression (LS-SVR) was applied to relate
concentration of both the compounds to their CL profiles. The parameters of the model, ...