Sensitive DNA impedance biosensor for detection of cancer, chronic lymphocytic leukemia, based on gold nanoparticles/gold modified electrode

Authors: Ali A Ensafi, M Taei, HR Rahmani, T Khayamian

Publication date: 2011/10/1

Journal name: Electrochimica Acta

Volume: 56

Issue: 24

Pages: 8176-8183

Publisher: Pergamon

A simple and sensitive DNA impedance sensor was prepared for the detection of chronic
lymphocytic leukemia. The DNA electrochemical biosensor is worked based on the
electrochemical impedance spectroscopic (EIS) detection of the sequence-specific DNA
related to chronic lymphocytic leukemia. The ssDNA probe was immobilized on the surface
of the gold nanoparticles. Compared to the bare gold electrode, the gold nanoparticles-
modified electrode could improve the density of the probe DNA attachment and hence the ...