Detection of DNA damage induced by chromium/glutathione/H< sub> 2</sub> O< sub> 2</sub> system at MWCNTs-poly (diallyldimethylammonium chloride) modified pencil graphite electrode using methylene blue as an electroactive probe

Authors: Ali A Ensafi, Maryam Amini, Behzad Rezaei

Publication date: 2012/12/13

Journal name: Sensors and Actuators B: Chemical

Publisher: Elsevier

A new electrochemical biosensor for direct detection of DNA damage is presented by
chromium/glutathione/H2O2 system using methylene blue (MB) as an electroactive probe. In
this work, MWCNTs modified poly (diallyldimethylammonium chloride), MWCNTs–PDDA,
nanoparticles were prepared. Then, a pencil graphite electrode (PGE) was modified with
MWCNTs–PDDA nanoparticles. Finally, a double strain DNA (ds-DNA) was assembled on
the surface of the modified electrode. To detect the DNA damage, the modified electrode ...

 

http://www.sciencedirect.com/science/article/pii/S0925400512013263